The Baltimore Orioles had the longest losing streak within the 2021 regular season at 19 straight games. During this streak they lost to their opponents by an average of 5.7 runs. The streak started on Aug 3, 2021 and ended on Aug 24, 2021.
Yes, multiple losing streaks during the 2021 MLB season are in the all time top 50 losing streaks in the same season. The 19 game losing streak by the Baltimore Orioles was the 10th longest same season losing streak in MLB history. The 17 game losing streak by the Arizona Diamondbacks was the 20th longest. The 14 game losing streak by the Baltimore Orioles was the 45th longest.
| Team | Losing Streak | Start | End | Avg Margin of Defeat | |
|---|---|---|---|---|---|
| 1 | Baltimore Orioles | 19 | Aug 3 | Aug 24 | 5.7 runs |
| 2 | Arizona Diamondbacks | 17 | Jun 2 | Jun 20 | 3.2 runs |
| 3 | Baltimore Orioles | 14 | May 18 | May 31 | 3.2 runs |
| 4 | Arizona Diamondbacks | 13 | May 16 | May 29 | 3.0 runs |
| 5 | Chicago Cubs | 12 | Aug 5 | Aug 16 | 4.8 runs |
| Texas Rangers | 12 | Jul 10 | Jul 25 | 5.0 runs | |
| 7 | Chicago Cubs | 11 | Jun 25 | Jul 6 | 4.4 runs |
| Kansas City Royals | 11 | May 2 | May 13 | 3.7 runs | |
| 9 | Pittsburgh Pirates | 10 | Jun 6 | Jun 16 | 2.7 runs |
| 10 | Cleveland Indians | 9 | Jun 30 | Jul 7 | 3.7 runs |
| Kansas City Royals | 9 | Jun 23 | Jul 1 | 4.9 runs | |
| Texas Rangers | 9 | May 25 | Jun 3 | 2.8 runs | |
| 13 | Baltimore Orioles | 8 | Jun 9 | Jun 17 | 4.5 runs |
| Miami Marlins | 8 | Aug 16 | Aug 24 | 3.8 runs | |
| Miami Marlins | 8 | May 27 | Jun 5 | 2.6 runs | |
| Pittsburgh Pirates | 8 | Aug 4 | Aug 12 | 4.0 runs | |
| 17 | Chicago Cubs | 7 | Sep 21 | Sep 28 | 3.3 runs |
| Cincinnati Reds | 7 | Apr 18 | Apr 25 | 2.3 runs | |
| Colorado Rockies | 7 | Apr 9 | Apr 17 | 2.7 runs | |
| Miami Marlins | 7 | Sep 21 | Sep 28 | 3.6 runs | |
| New York Yankees | 7 | Sep 4 | Sep 10 | 3.7 runs | |
| San Diego Padres | 7 | Sep 24 | Oct 1 | 2.6 runs | |
| Tampa Bay Rays | 7 | Jun 15 | Jun 22 | 2.6 runs | |
| Washington Nationals | 7 | Aug 28 | Sep 4 | 3.3 runs | |
| Washington Nationals | 7 | Aug 8 | Aug 15 | 2.7 runs | |
| 26 | Arizona Diamondbacks | 6 | May 4 | May 9 | 3.5 runs |
| Arizona Diamondbacks | 6 | Sep 3 | Sep 10 | 2.7 runs | |
| Baltimore Orioles | 6 | Jun 19 | Jun 24 | 6.3 runs | |
| Detroit Tigers | 6 | Apr 29 | May 4 | 5.2 runs | |
| Houston Astros | 6 | Apr 9 | Apr 16 | 3.5 runs | |
| Kansas City Royals | 6 | Jun 11 | Jun 16 | 3.7 runs | |
| Los Angeles Angels | 6 | Sep 17 | Sep 22 | 3.8 runs | |
| Milwaukee Brewers | 6 | May 2 | May 7 | 3.7 runs | |
| Oakland Athletics | 6 | Apr 1 | Apr 6 | 6.2 runs | |
| Oakland Athletics | 6 | Aug 21 | Aug 27 | 2.5 runs | |
| Pittsburgh Pirates | 6 | May 21 | May 27 | 6.0 runs | |
| Pittsburgh Pirates | 6 | Jun 28 | Jul 3 | 5.5 runs | |
| Pittsburgh Pirates | 6 | Apr 3 | Apr 8 | 4.8 runs | |
| Pittsburgh Pirates | 6 | Aug 31 | Sep 5 | 1.8 runs | |
| Seattle Mariners | 6 | May 17 | May 23 | 6.0 runs | |
| St. Louis Cardinals | 6 | Jun 2 | Jun 8 | 4.7 runs | |
| Texas Rangers | 6 | Aug 3 | Aug 8 | 4.8 runs | |
| Texas Rangers | 6 | May 10 | May 16 | 2.7 runs | |
| Texas Rangers | 6 | Jun 13 | Jun 20 | 2.3 runs | |
| Toronto Blue Jays | 6 | May 19 | May 24 | 2.8 runs | |
| Washington Nationals | 6 | Jul 8 | Jul 17 | 5.5 runs | |
| 47 | Arizona Diamondbacks | 5 | Aug 27 | Aug 31 | 3.2 runs |
| Arizona Diamondbacks | 5 | Sep 26 | Oct 1 | 1.8 runs | |
| Baltimore Orioles | 5 | Jul 7 | Jul 16 | 6.6 runs | |
| Baltimore Orioles | 5 | Sep 11 | Sep 15 | 6.2 runs | |
| Boston Red Sox | 5 | Jul 29 | Aug 3 | 4.6 runs | |
| Chicago Cubs | 5 | Apr 24 | Apr 28 | 4.6 runs | |
| Chicago White Sox | 5 | Jun 17 | Jun 22 | 4.4 runs | |
| Cincinnati Reds | 5 | Jun 17 | Jun 21 | 2.6 runs | |
| Colorado Rockies | 5 | Sep 23 | Sep 27 | 3.4 runs | |
| Colorado Rockies | 5 | May 7 | May 12 | 3.4 runs | |
| Colorado Rockies | 5 | May 25 | May 29 | 3.2 runs | |
| Colorado Rockies | 5 | May 15 | May 19 | 2.6 runs | |
| Detroit Tigers | 5 | Apr 15 | Apr 21 | 3.2 runs | |
| Detroit Tigers | 5 | Apr 22 | Apr 26 | 2.4 runs | |
| Kansas City Royals | 5 | Jun 5 | Jun 9 | 3.8 runs | |
| Los Angeles Angels | 5 | Jun 20 | Jun 26 | 4.8 runs | |
| Los Angeles Angels | 5 | May 2 | May 6 | 3.6 runs | |
| Miami Marlins | 5 | Aug 6 | Aug 10 | 5.2 runs | |
| Milwaukee Brewers | 5 | Sep 19 | Sep 23 | 3.4 runs | |
| Milwaukee Brewers | 5 | Jun 14 | Jun 18 | 3.0 runs | |
| Minnesota Twins | 5 | May 8 | May 14 | 4.4 runs | |
| Minnesota Twins | 5 | Jun 29 | Jul 3 | 4.0 runs | |
| Minnesota Twins | 5 | Apr 10 | Apr 14 | 2.4 runs | |
| New York Mets | 5 | Sep 21 | Sep 26 | 3.8 runs | |
| New York Mets | 5 | Sep 13 | Sep 18 | 3.6 runs | |
| New York Mets | 5 | Aug 13 | Aug 17 | 3.0 runs | |
| New York Yankees | 5 | Apr 13 | Apr 18 | 3.2 runs | |
| Pittsburgh Pirates | 5 | Apr 28 | May 3 | 3.8 runs | |
| Pittsburgh Pirates | 5 | Aug 14 | Aug 18 | 3.6 runs | |
| San Diego Padres | 5 | Sep 10 | Sep 14 | 5.0 runs | |
| San Diego Padres | 5 | Sep 17 | Sep 22 | 2.2 runs | |
| Seattle Mariners | 5 | May 8 | May 13 | 3.8 runs | |
| St. Louis Cardinals | 5 | Jun 20 | Jun 25 | 3.6 runs | |
| Tampa Bay Rays | 5 | Jun 27 | Jul 3 | 5.0 runs | |
| Texas Rangers | 5 | Sep 19 | Sep 23 | 3.8 runs | |
| Toronto Blue Jays | 5 | Jun 14 | Jun 18 | 2.6 runs | |
| Washington Nationals | 5 | May 27 | May 31 | 3.0 runs | |
| Washington Nationals | 5 | Sep 28 | Oct 3 | 2.6 runs | |
| Washington Nationals | 5 | Aug 2 | Aug 6 | 2.4 runs | |
| Washington Nationals | 5 | Jul 21 | Jul 26 | 2.2 runs | |
| Washington Nationals | 5 | Apr 7 | Apr 11 | 2.2 runs |
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