| 7-9 | Missed Playoffs |
| Record | Outcome |
The Buffalo Bills finished the regular season with a 7-9 record. They went 4-4 at home and 3-5 on the road.
No, the Bills didn't make the Playoffs in 2016.
The Buffalo Bills finished the regular season with a point differential of +21. Based on their point differential and their pythagorean expectation, the Bills could have been expected to have about 8.5 wins.
In close, one-score games, the 2016 Buffalo Bills went 2-6. In games decided by a field goal or less, the Bills went 0-2.
During the regular season, the 2016 Buffalo Bills went 0-1 in overtime games.
| Week | Date | Opponent | Score | |
|---|---|---|---|---|
| 1 | Sun, Sep 11, 2016 Sun, Sep 11 | @ Baltimore Ravens Ravens | Loss L 7 - 13 | |
| 2 | Thu, Sep 15, 2016 Thu, Sep 15 | vs New York Jets Jets | Loss L 31 - 37 | |
| 3 | Sun, Sep 25, 2016 Sun, Sep 25 | vs Arizona Cardinals Cardinals | Win W 33 - 18 | |
| 4 | Sun, Oct 2, 2016 Sun, Oct 2 | @ New England Patriots Patriots | Win W 16 - 0 | |
| 5 | Sun, Oct 9, 2016 Sun, Oct 9 | @ Los Angeles Rams Rams | Win W 30 - 19 | |
| 6 | Sun, Oct 16, 2016 Sun, Oct 16 | vs San Francisco 49ers 49ers | Win W 45 - 16 | |
| 7 | Sun, Oct 23, 2016 Sun, Oct 23 | @ Miami Dolphins Dolphins | Loss L 25 - 28 | |
| 8 | Sun, Oct 30, 2016 Sun, Oct 30 | vs New England Patriots Patriots | Loss L 25 - 41 | |
| 9 | Mon, Nov 7, 2016 Mon, Nov 7 | @ Seattle Seahawks Seahawks | Loss L 25 - 31 | |
| 11 | Sun, Nov 20, 2016 Sun, Nov 20 | @ Cincinnati Bengals Bengals | Win W 16 - 12 | |
| 12 | Sun, Nov 27, 2016 Sun, Nov 27 | vs Jacksonville Jaguars Jaguars | Win W 28 - 21 | |
| 13 | Sun, Dec 4, 2016 Sun, Dec 4 | @ Oakland Raiders Raiders | Loss L 24 - 38 | |
| 14 | Sun, Dec 11, 2016 Sun, Dec 11 | vs Pittsburgh Steelers Steelers | Loss L 20 - 27 | |
| 15 | Sun, Dec 18, 2016 Sun, Dec 18 | vs Cleveland Browns Browns | Win W 33 - 13 | |
| 16 | Sat, Dec 24, 2016 Sat, Dec 24 | vs Miami Dolphins Dolphins | Loss L 31 - 34 | OT |
| 17 | Sun, Jan 1, 2017 Sun, Jan 1, 2017 | @ New York Jets Jets | Loss L 10 - 30 | |
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