| 11-6 | Lost Divisional |
| Record | Outcome |
The Buffalo Bills finished the regular season with a 11-6 record. They went 6-3 at home and 5-3 on the road. Including the playoffs, the Buffalo Bills went 12-7. Their final game was a loss in the Divisional Round to the Kansas City Chiefs.
The 2021 Buffalo Bills played in the East Division of the American Football Conference.
During the regular season, the 2021 Buffalo Bills went 5-1 against their AFC East opponents.
| Opponent | Record | Win Percentage % | Point Differential |
|---|---|---|---|
| Miami Dolphins | 2-0 | 100% | +50 |
| New York Jets | 2-0 | 100% | +45 |
| New England Patriots | 1-1 | 50% | +8 |
Yes, the Buffalo Bills made the Playoffs in 2021. They won their first game against the New England Patriots in the Wild Card Round. They eventually lost against the Kansas City Chiefs in the Divisional Round.
The Buffalo Bills finished the regular season with a point differential of +194. Based on their point differential and their pythagorean expectation, the Bills could have been expected to have about 13.1 wins, or a 13-4 record in the regular season.
In close, one-score games, the 2021 Buffalo Bills went 0-5. In games decided by a field goal or less, the Bills went 0-3.
During the regular season, the 2021 Buffalo Bills went 0-1 in overtime games.
The longest win streak during the regular season for the 2021 Buffalo Bills was a 4 game winning streak on 2 separate stretches during the season.
The longest losing streak that the Buffalo Bills had during the 2021 regular season was 2 games, which only happened once during the season.
= Playoff Team
Bold = Division Opponent
| Week | Date | Opponent | Score | |
|---|---|---|---|---|
| Regular Season | ||||
| 1 | Sun, Sep 12, 2021 Sun, Sep 12 | vs Pittsburgh Steelers | Loss 16 - 23 | |
| 2 | Sun, Sep 19, 2021 Sun, Sep 19 | @ Miami Dolphins | Win 35 - 0 | |
| 3 | Sun, Sep 26, 2021 Sun, Sep 26 | vs Washington Football Team | Win 43 - 21 | |
| 4 | Sun, Oct 3, 2021 Sun, Oct 3 | vs Houston Texans | Win 40 - 0 | |
| 5 | Sun, Oct 10, 2021 Sun, Oct 10 | @ Kansas City Chiefs | Win 38 - 20 | |
| 6 | Mon, Oct 18, 2021 Mon, Oct 18 | @ Tennessee Titans | Loss 31 - 34 | |
| 8 | Sun, Oct 31, 2021 Sun, Oct 31 | vs Miami Dolphins | Win 26 - 11 | |
| 9 | Sun, Nov 7, 2021 Sun, Nov 7 | @ Jacksonville Jaguars | Loss 6 - 9 | |
| 10 | Sun, Nov 14, 2021 Sun, Nov 14 | @ New York Jets | Win 45 - 17 | |
| 11 | Sun, Nov 21, 2021 Sun, Nov 21 | vs Indianapolis Colts | Loss 15 - 41 | |
| 12 | Thu, Nov 25, 2021 Thu, Nov 25 | @ New Orleans Saints | Win 31 - 6 | |
| 13 | Mon, Dec 6, 2021 Mon, Dec 6 | vs New England Patriots | Loss 10 - 14 | |
| 14 | Sun, Dec 12, 2021 Sun, Dec 12 | @ Tampa Bay Buccaneers | Loss 27 - 33 | OT |
| 15 | Sun, Dec 19, 2021 Sun, Dec 19 | vs Carolina Panthers | Win 31 - 14 | |
| 16 | Sun, Dec 26, 2021 Sun, Dec 26 | @ New England Patriots | Win 33 - 21 | |
| 17 | Sun, Jan 2, 2022 Sun, Jan 2, 2022 | vs Atlanta Falcons | Win 29 - 15 | |
| 18 | Sun, Jan 9, 2022 Sun, Jan 9, 2022 | vs New York Jets | Win 27 - 10 | |
| Playoffs | ||||
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| Wild Card Wild Card Round | Sat, Jan 15, 2022 Sat, Jan 15, 2022 | vs New England Patriots | Win 47 - 17 | |
| Divisional Divisional Round | Sun, Jan 23, 2022 Sun, Jan 23, 2022 | @ Kansas City Chiefs | Loss 36 - 42 | OT |
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