| 8-8 | Missed Playoffs |
| Record | Outcome |
The Buffalo Bills finished the regular season with a 8-8 record. They went 5-3 at home and 3-5 on the road.
The 2000 Buffalo Bills played in the East Division of the American Football Conference.
During the regular season, the 2000 Buffalo Bills went 2-6 against their AFC East opponents.
No, the Bills didn't make the Playoffs in 2000.
The Buffalo Bills finished the regular season with a point differential of -35. Based on their point differential and their pythagorean expectation, the Bills could have been expected to have about 7.0 wins, or a 7-9 record in the regular season.
In close, one-score games, the 2000 Buffalo Bills went 5-3. In games decided by a field goal or less, the Bills went 4-2.
During the regular season, the 2000 Buffalo Bills went 2-1 in overtime games.
The longest win streak during the regular season for the 2000 Buffalo Bills was a 4 game winning streak.
The longest losing streak that the Buffalo Bills had during the 2000 regular season was 4 games, which happened once during the season.
= Playoff Team
= Division Opponent
| Week | Date | Opponent | Score | |
|---|---|---|---|---|
| Regular Season | ||||
| 1 | Sun, Sep 3, 2000 Sun, Sep 3 | vs Tennessee Titans Titans | Win W 16 - 13 | |
| 2 | Sun, Sep 10, 2000 Sun, Sep 10 | vs Green Bay Packers Packers | Win W 27 - 18 | |
| 3 | Sun, Sep 17, 2000 Sun, Sep 17 | @ New York Jets Jets | Loss L 14 - 27 | |
| 5 | Sun, Oct 1, 2000 Sun, Oct 1 | vs Indianapolis Colts Colts | Loss L 16 - 18 | |
| 6 | Sun, Oct 8, 2000 Sun, Oct 8 | @ Miami Dolphins Dolphins | Loss L 13 - 22 | |
| 7 | Sun, Oct 15, 2000 Sun, Oct 15 | vs San Diego Chargers Chargers | Win W 27 - 24 | OT |
| 8 | Sun, Oct 22, 2000 Sun, Oct 22 | @ Minnesota Vikings Vikings | Loss L 27 - 31 | |
| 9 | Sun, Oct 29, 2000 Sun, Oct 29 | vs New York Jets Jets | Win W 23 - 20 | |
| 10 | Sun, Nov 5, 2000 Sun, Nov 5 | @ New England Patriots Patriots | Win W 16 - 13 | OT |
| 11 | Sun, Nov 12, 2000 Sun, Nov 12 | vs Chicago Bears Bears | Win W 20 - 3 | |
| 12 | Sun, Nov 19, 2000 Sun, Nov 19 | @ Kansas City Chiefs Chiefs | Win W 21 - 17 | |
| 13 | Sun, Nov 26, 2000 Sun, Nov 26 | @ Tampa Bay Buccaneers Buccaneers | Loss L 17 - 31 | |
| 14 | Sun, Dec 3, 2000 Sun, Dec 3 | vs Miami Dolphins Dolphins | Loss L 6 - 33 | |
| 15 | Mon, Dec 11, 2000 Mon, Dec 11 | @ Indianapolis Colts Colts | Loss L 20 - 44 | |
| 16 | Sun, Dec 17, 2000 Sun, Dec 17 | vs New England Patriots Patriots | Loss L 10 - 13 | OT |
| 17 | Sat, Dec 23, 2000 Sat, Dec 23 | @ Seattle Seahawks Seahawks | Win W 42 - 23 | |
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