| 10-7 | Lost Conf Champ |
| Record | Outcome |
The San Francisco 49ers finished the regular season with a 10-7 record. They went 4-4 at home and 6-3 on the road. Including the playoffs, the San Francisco 49ers went 12-8. Their final game was a loss in the Conference Championship to the Los Angeles Rams.
The 2021 San Francisco 49ers played in the West Division of the National Football Conference.
During the regular season, the 2021 San Francisco 49ers went 2-4 against their NFC West opponents.
| Opponent | Record | Win Percentage % | Point Differential |
|---|---|---|---|
| Los Angeles Rams | 2-0 | 100% | +24 |
| Seattle Seahawks | 0-2 | 0% | -14 |
| Arizona Cardinals | 0-2 | 0% | -21 |
Yes, the San Francisco 49ers made the Playoffs in 2021. They won their first game against the Green Bay Packers in the Divisional Round. They eventually lost against the Los Angeles Rams in the Conference Championship.
The San Francisco 49ers finished the regular season with a point differential of +62. Based on their point differential and their pythagorean expectation, the 49ers could have been expected to have about 10.1 wins, or a 10-7 record in the regular season.
In close, one-score games, the 2021 San Francisco 49ers went 5-5. In games decided by a field goal or less, the 49ers went 2-2.
During the regular season, the 2021 San Francisco 49ers went 2-0 in overtime games.
The longest win streak during the regular season for the 2021 San Francisco 49ers was a 3 game winning streak.
The longest losing streak that the San Francisco 49ers had during the 2021 regular season was 4 games, which happened once during the season.
= Playoff Team
Bold = Division Opponent
| Week | Date | Opponent | Score | |
|---|---|---|---|---|
| Regular Season | ||||
| 1 | Sun, Sep 12, 2021 Sun, Sep 12 | @ Detroit Lions | Win 41 - 33 | |
| 2 | Sun, Sep 19, 2021 Sun, Sep 19 | @ Philadelphia Eagles | Win 17 - 11 | |
| 3 | Sun, Sep 26, 2021 Sun, Sep 26 | vs Green Bay Packers | Loss 28 - 30 | |
| 4 | Sun, Oct 3, 2021 Sun, Oct 3 | vs Seattle Seahawks | Loss 21 - 28 | |
| 5 | Sun, Oct 10, 2021 Sun, Oct 10 | @ Arizona Cardinals | Loss 10 - 17 | |
| 7 | Sun, Oct 24, 2021 Sun, Oct 24 | vs Indianapolis Colts | Loss 18 - 30 | |
| 8 | Sun, Oct 31, 2021 Sun, Oct 31 | @ Chicago Bears | Win 33 - 22 | |
| 9 | Sun, Nov 7, 2021 Sun, Nov 7 | vs Arizona Cardinals | Loss 17 - 31 | |
| 10 | Mon, Nov 15, 2021 Mon, Nov 15 | vs Los Angeles Rams | Win 31 - 10 | |
| 11 | Sun, Nov 21, 2021 Sun, Nov 21 | @ Jacksonville Jaguars | Win 30 - 10 | |
| 12 | Sun, Nov 28, 2021 Sun, Nov 28 | vs Minnesota Vikings | Win 34 - 26 | |
| 13 | Sun, Dec 5, 2021 Sun, Dec 5 | @ Seattle Seahawks | Loss 23 - 30 | |
| 14 | Sun, Dec 12, 2021 Sun, Dec 12 | @ Cincinnati Bengals | Win 26 - 23 | OT |
| 15 | Sun, Dec 19, 2021 Sun, Dec 19 | vs Atlanta Falcons | Win 31 - 13 | |
| 16 | Thu, Dec 23, 2021 Thu, Dec 23 | @ Tennessee Titans | Loss 17 - 20 | |
| 17 | Sun, Jan 2, 2022 Sun, Jan 2, 2022 | vs Houston Texans | Win 23 - 7 | |
| 18 | Sun, Jan 9, 2022 Sun, Jan 9, 2022 | @ Los Angeles Rams | Win 27 - 24 | OT |
| Playoffs | ||||
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|
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| Wild Card Wild Card Round | Sun, Jan 16, 2022 Sun, Jan 16, 2022 | @ Dallas Cowboys | Win 23 - 17 | |
| Divisional Divisional Round | Sat, Jan 22, 2022 Sat, Jan 22, 2022 | @ Green Bay Packers | Win 13 - 10 | |
| Conf Champ Conference Championship | Sun, Jan 30, 2022 Sun, Jan 30, 2022 | @ Los Angeles Rams | Loss 17 - 20 | |
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