| 10-7 | Lost Conf Champ |
| Record | Outcome |
The San Francisco 49ers finished the regular season with a 10-7 record. They went 4-4 at home and 6-3 on the road. Including the playoffs, the San Francisco 49ers went 12-8. Their final game was a loss in the Conference Championship to the Los Angeles Rams.
The 2021 San Francisco 49ers played in the West Division of the National Football Conference.
During the regular season, the 2021 San Francisco 49ers went 2-4 against their NFC West opponents.
Yes, the San Francisco 49ers made the Playoffs in 2021. They won their first game against the Green Bay Packers in the Divisional Round. They eventually lost against the Los Angeles Rams in the Conference Championship.
The San Francisco 49ers finished the regular season with a point differential of +62. Based on their point differential and their pythagorean expectation, the 49ers could have been expected to have about 10.1 wins, or a 10-7 record in the regular season.
In close, one-score games, the 2021 San Francisco 49ers went 5-5. In games decided by a field goal or less, the 49ers went 2-2.
During the regular season, the 2021 San Francisco 49ers went 2-0 in overtime games.
The longest win streak during the regular season for the 2021 San Francisco 49ers was a 3 game winning streak.
The longest losing streak that the San Francisco 49ers had during the 2021 regular season was 4 games, which happened once during the season.
= Playoff Team
= Division Opponent
| Week | Date | Opponent | Score | |
|---|---|---|---|---|
| Regular Season | ||||
| 1 | Sun, Sep 12, 2021 Sun, Sep 12 | @ Detroit Lions Lions | Win W 41 - 33 | |
| 2 | Sun, Sep 19, 2021 Sun, Sep 19 | @ Philadelphia Eagles Eagles | Win W 17 - 11 | |
| 3 | Sun, Sep 26, 2021 Sun, Sep 26 | vs Green Bay Packers Packers | Loss L 28 - 30 | |
| 4 | Sun, Oct 3, 2021 Sun, Oct 3 | vs Seattle Seahawks Seahawks | Loss L 21 - 28 | |
| 5 | Sun, Oct 10, 2021 Sun, Oct 10 | @ Arizona Cardinals Cardinals | Loss L 10 - 17 | |
| 7 | Sun, Oct 24, 2021 Sun, Oct 24 | vs Indianapolis Colts Colts | Loss L 18 - 30 | |
| 8 | Sun, Oct 31, 2021 Sun, Oct 31 | @ Chicago Bears Bears | Win W 33 - 22 | |
| 9 | Sun, Nov 7, 2021 Sun, Nov 7 | vs Arizona Cardinals Cardinals | Loss L 17 - 31 | |
| 10 | Mon, Nov 15, 2021 Mon, Nov 15 | vs Los Angeles Rams Rams | Win W 31 - 10 | |
| 11 | Sun, Nov 21, 2021 Sun, Nov 21 | @ Jacksonville Jaguars Jaguars | Win W 30 - 10 | |
| 12 | Sun, Nov 28, 2021 Sun, Nov 28 | vs Minnesota Vikings Vikings | Win W 34 - 26 | |
| 13 | Sun, Dec 5, 2021 Sun, Dec 5 | @ Seattle Seahawks Seahawks | Loss L 23 - 30 | |
| 14 | Sun, Dec 12, 2021 Sun, Dec 12 | @ Cincinnati Bengals Bengals | Win W 26 - 23 | OT |
| 15 | Sun, Dec 19, 2021 Sun, Dec 19 | vs Atlanta Falcons Falcons | Win W 31 - 13 | |
| 16 | Thu, Dec 23, 2021 Thu, Dec 23 | @ Tennessee Titans Titans | Loss L 17 - 20 | |
| 17 | Sun, Jan 2, 2022 Sun, Jan 2, 2022 | vs Houston Texans Texans | Win W 23 - 7 | |
| 18 | Sun, Jan 9, 2022 Sun, Jan 9, 2022 | @ Los Angeles Rams Rams | Win W 27 - 24 | OT |
| Playoffs | ||||
|
|
||||
| Wild Card Wild Card Round | Sun, Jan 16, 2022 Sun, Jan 16, 2022 | @ Dallas Cowboys Cowboys | Win W 23 - 17 | |
| Divisional Divisional Round | Sat, Jan 22, 2022 Sat, Jan 22, 2022 | @ Green Bay Packers Packers | Win W 13 - 10 | |
| Conf Champ Conference Championship | Sun, Jan 30, 2022 Sun, Jan 30, 2022 | @ Los Angeles Rams Rams | Loss L 17 - 20 | |
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