The Chicago White Sox had the longest losing streak within the 1921 regular season at 11 straight games. During this streak they lost to their opponents by an average of 4.1 runs. The streak started on Sep 14, 1921 and ended on Sep 24, 1921.
| Team | Losing Streak | Start | End | Avg Margin of Defeat | |
|---|---|---|---|---|---|
| 1 | Chicago White Sox | 11 | Sep 14 | Sep 24 | 4.1 runs |
| 2 | Philadelphia Athletics | 10 | Sep 9 | Sep 19 | 6.6 runs |
| Washington Senators | 10 | Aug 26 | Sep 5 | 4.6 runs | |
| 4 | Detroit Tigers | 9 | Jun 11 | Jun 19 | 2.9 runs |
| 5 | Boston Red Sox | 8 | Jun 29 | Jul 5 | 2.9 runs |
| Philadelphia Athletics | 8 | May 13 | May 20 | 3.9 runs | |
| 7 | Boston Braves | 7 | Aug 24 | Aug 29 | 2.6 runs |
| Chicago Cubs | 7 | May 24 | May 30 | 5.3 runs | |
| Detroit Tigers | 7 | Sep 20 | Oct 2 | 4.1 runs | |
| Philadelphia Athletics | 7 | Jul 16 | Jul 21 | 1.9 runs | |
| Philadelphia Phillies | 7 | Jun 20 | Jun 25 | 5.4 runs | |
| Philadelphia Phillies | 7 | Jun 9 | Jun 17 | 4.9 runs | |
| 13 | Boston Braves | 6 | Apr 19 | Apr 25 | 3.8 runs |
| Boston Red Sox | 6 | May 19 | May 25 | 3.5 runs | |
| Brooklyn Robins | 6 | Jun 7 | Jun 12 | 6.2 runs | |
| Chicago Cubs | 6 | Aug 11 | Aug 16 | 2.0 runs | |
| Chicago Cubs | 6 | Sep 4 | Sep 7 | 1.5 runs | |
| Chicago White Sox | 6 | Jun 24 | Jun 30 | 2.0 runs | |
| Cincinnati Reds | 6 | May 14 | May 19 | 3.2 runs | |
| Cincinnati Reds | 6 | Jun 18 | Jun 26 | 3.0 runs | |
| Detroit Tigers | 6 | Jul 14 | Jul 19 | 2.8 runs | |
| New York Giants | 6 | Jun 6 | Jun 13 | 4.0 runs | |
| Philadelphia Athletics | 6 | Jul 28 | Aug 4 | 5.3 runs | |
| Philadelphia Athletics | 6 | Sep 27 | Oct 2 | 3.5 runs | |
| Philadelphia Phillies | 6 | Jun 29 | Jul 4 | 2.7 runs | |
| Philadelphia Phillies | 6 | Apr 30 | May 9 | 2.0 runs | |
| Pittsburgh Pirates | 6 | Aug 23 | Aug 27 | 3.7 runs | |
| St. Louis Cardinals | 6 | Apr 20 | Apr 29 | 2.3 runs | |
| 29 | Boston Braves | 5 | Apr 28 | May 3 | 5.4 runs |
| Brooklyn Robins | 5 | May 18 | May 22 | 4.2 runs | |
| Brooklyn Robins | 5 | Apr 14 | Apr 19 | 3.4 runs | |
| Brooklyn Robins | 5 | Sep 14 | Sep 18 | 1.6 runs | |
| Chicago Cubs | 5 | Jul 24 | Jul 29 | 4.4 runs | |
| Chicago Cubs | 5 | Apr 26 | May 2 | 1.8 runs | |
| Chicago White Sox | 5 | Jul 23 | Jul 28 | 2.6 runs | |
| Cincinnati Reds | 5 | Jul 4 | Jul 11 | 3.6 runs | |
| Cleveland Indians | 5 | Jul 31 | Aug 5 | 4.0 runs | |
| Cleveland Indians | 5 | Jun 3 | Jun 8 | 3.2 runs | |
| Cleveland Indians | 5 | May 12 | May 16 | 3.2 runs | |
| New York Yankees | 5 | Apr 22 | Apr 27 | 2.8 runs | |
| Philadelphia Athletics | 5 | Aug 24 | Aug 28 | 5.4 runs | |
| Philadelphia Athletics | 5 | Apr 16 | Apr 21 | 3.8 runs | |
| St. Louis Cardinals | 5 | Jun 14 | Jun 18 | 5.0 runs | |
| Washington Senators | 5 | Jul 18 | Jul 23 | 2.6 runs | |
| 45 | Boston Red Sox | 4 | Sep 30 | Oct 2 | 3.2 runs |
| Boston Red Sox | 4 | Jun 23 | Jun 25 | 2.2 runs | |
| Brooklyn Robins | 4 | Sep 6 | Sep 11 | 4.2 runs | |
| Brooklyn Robins | 4 | May 13 | May 16 | 1.8 runs | |
| Chicago Cubs | 4 | Jul 30 | Aug 3 | 4.0 runs | |
| Chicago Cubs | 4 | Aug 27 | Aug 30 | 3.8 runs | |
| Chicago Cubs | 4 | Jul 12 | Jul 14 | 1.5 runs | |
| Chicago White Sox | 4 | Aug 5 | Aug 8 | 5.8 runs | |
| Chicago White Sox | 4 | Apr 30 | May 4 | 5.0 runs | |
| Chicago White Sox | 4 | Aug 26 | Aug 30 | 2.2 runs | |
| Cincinnati Reds | 4 | Jun 28 | Jul 2 | 4.5 runs | |
| Detroit Tigers | 4 | Aug 12 | Aug 15 | 1.8 runs | |
| Detroit Tigers | 4 | Jul 30 | Aug 2 | 1.8 runs | |
| New York Giants | 4 | Apr 25 | Apr 28 | 1.8 runs | |
| Philadelphia Athletics | 4 | Jul 10 | Jul 13 | 4.5 runs | |
| Philadelphia Phillies | 4 | Sep 3 | Sep 5 | 5.8 runs | |
| Philadelphia Phillies | 4 | Jul 18 | Jul 20 | 5.0 runs | |
| Philadelphia Phillies | 4 | May 10 | May 14 | 4.8 runs | |
| Philadelphia Phillies | 4 | Jun 4 | Jun 7 | 4.5 runs | |
| Philadelphia Phillies | 4 | Aug 16 | Aug 19 | 3.8 runs | |
| Philadelphia Phillies | 4 | Aug 3 | Aug 6 | 3.8 runs | |
| Philadelphia Phillies | 4 | Sep 16 | Sep 19 | 2.2 runs | |
| Pittsburgh Pirates | 4 | Jul 26 | Jul 30 | 1.8 runs | |
| St. Louis Browns | 4 | May 26 | May 29 | 4.2 runs | |
| St. Louis Browns | 4 | Jul 3 | Jul 5 | 2.8 runs | |
| St. Louis Browns | 4 | Jun 15 | Jun 18 | 2.0 runs | |
| St. Louis Browns | 4 | Apr 21 | Apr 24 | 1.8 runs | |
| St. Louis Cardinals | 4 | Jul 21 | Jul 26 | 3.2 runs | |
| St. Louis Cardinals | 4 | Jul 11 | Jul 14 | 3.2 runs |
In the 1921 MLB season, there were no losing streaks that were in the all time top 50 losing streaks in the same season.
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