| 7-9 | Missed Playoffs |
| Record | Outcome |
The Buffalo Bills finished the regular season with a 7-9 record. They went 4-4 at home and 3-5 on the road.
No, the Bills didn't make the Playoffs in 2007.
The Buffalo Bills finished the regular season with a point differential of -102. Based on their point differential and their pythagorean expectation, the Bills could have been expected to have about 4.9 wins.
In close, one-score games, the 2007 Buffalo Bills went 4-4. In games decided by a field goal or less, the Bills went 3-2.
The 2007 Buffalo Bills did not play any overtime games in the regular season.
| Week | Date | Opponent | Score | |
|---|---|---|---|---|
| 1 | Sun, Sep 9, 2007 Sun, Sep 9 | vs Denver Broncos Broncos | Loss L 14 - 15 | |
| 2 | Sun, Sep 16, 2007 Sun, Sep 16 | @ Pittsburgh Steelers Steelers | Loss L 3 - 26 | |
| 3 | Sun, Sep 23, 2007 Sun, Sep 23 | @ New England Patriots Patriots | Loss L 7 - 38 | |
| 4 | Sun, Sep 30, 2007 Sun, Sep 30 | vs New York Jets Jets | Win W 17 - 14 | |
| 5 | Mon, Oct 8, 2007 Mon, Oct 8 | vs Dallas Cowboys Cowboys | Loss L 24 - 25 | |
| 7 | Sun, Oct 21, 2007 Sun, Oct 21 | vs Baltimore Ravens Ravens | Win W 19 - 14 | |
| 8 | Sun, Oct 28, 2007 Sun, Oct 28 | @ New York Jets Jets | Win W 13 - 3 | |
| 9 | Sun, Nov 4, 2007 Sun, Nov 4 | vs Cincinnati Bengals Bengals | Win W 33 - 21 | |
| 10 | Sun, Nov 11, 2007 Sun, Nov 11 | @ Miami Dolphins Dolphins | Win W 13 - 10 | |
| 11 | Sun, Nov 18, 2007 Sun, Nov 18 | vs New England Patriots Patriots | Loss L 10 - 56 | |
| 12 | Sun, Nov 25, 2007 Sun, Nov 25 | @ Jacksonville Jaguars Jaguars | Loss L 14 - 36 | |
| 13 | Sun, Dec 2, 2007 Sun, Dec 2 | @ Washington Redskins Redskins | Win W 17 - 16 | |
| 14 | Sun, Dec 9, 2007 Sun, Dec 9 | vs Miami Dolphins Dolphins | Win W 38 - 17 | |
| 15 | Sun, Dec 16, 2007 Sun, Dec 16 | @ Cleveland Browns Browns | Loss L 0 - 8 | |
| 16 | Sun, Dec 23, 2007 Sun, Dec 23 | vs New York Giants Giants | Loss L 21 - 38 | |
| 17 | Sun, Dec 30, 2007 Sun, Dec 30 | @ Philadelphia Eagles Eagles | Loss L 9 - 17 | |
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