The 1949 Washington Senators, the 1949 St. Louis Browns and the 1949 Washington Senators share the MLB record for the longest losing streak within the same season at 11 straight games.
In the 1949 MLB season, there were no losing streaks that were in the all time top 50 losing streaks in the same season.
| Team | Losing Streak | Start | End | Avg Margin of Defeat | |
|---|---|---|---|---|---|
| 1 | Washington Senators | 11 | Aug 12 | Aug 21 | 4.4 runs |
| St. Louis Browns | 11 | May 26 | Jun 5 | 3.8 runs | |
| Washington Senators | 11 | Jul 16 | Jul 26 | 2.8 runs | |
| 4 | St. Louis Browns | 10 | Apr 30 | May 8 | 2.2 runs |
| 5 | Boston Braves | 9 | Sep 2 | Sep 8 | 4.2 runs |
| 6 | St. Louis Browns | 8 | Aug 2 | Aug 9 | 7.0 runs |
| Pittsburgh Pirates | 8 | Aug 28 | Sep 5 | 5.1 runs | |
| Chicago Cubs | 8 | Jul 27 | Aug 3 | 4.2 runs | |
| Boston Red Sox | 8 | Jun 28 | Jul 4 | 2.8 runs | |
| 10 | Cincinnati Reds | 7 | Jun 7 | Jun 14 | 5.4 runs |
| Washington Senators | 7 | Aug 1 | Aug 7 | 4.6 runs | |
| Washington Senators | 7 | Apr 19 | Apr 25 | 3.9 runs | |
| St. Louis Browns | 7 | Apr 20 | Apr 26 | 3.7 runs | |
| St. Louis Browns | 7 | Sep 14 | Sep 19 | 3.6 runs | |
| Pittsburgh Pirates | 7 | May 21 | May 28 | 3.4 runs | |
| St. Louis Browns | 7 | Sep 4 | Sep 10 | 3.1 runs | |
| Chicago Cubs | 7 | Jun 12 | Jun 18 | 2.7 runs | |
| 18 | Chicago White Sox | 6 | Jul 24 | Jul 29 | 4.7 runs |
| Philadelphia Athletics | 6 | Sep 1 | Sep 5 | 4.3 runs | |
| Cincinnati Reds | 6 | Aug 7 | Aug 13 | 4.3 runs | |
| Cleveland Indians | 6 | Sep 18 | Sep 24 | 4.0 runs | |
| St. Louis Browns | 6 | Aug 12 | Aug 16 | 3.8 runs | |
| Philadelphia Athletics | 6 | Jul 7 | Jul 14 | 3.7 runs | |
| Chicago White Sox | 6 | Aug 26 | Aug 30 | 3.2 runs | |
| Detroit Tigers | 6 | May 20 | May 25 | 3.2 runs | |
| Cincinnati Reds | 6 | Jul 8 | Jul 15 | 3.0 runs | |
| New York Giants | 6 | Sep 10 | Sep 17 | 2.7 runs | |
| 28 | St. Louis Browns | 5 | Jun 22 | Jun 26 | 8.2 runs |
| Boston Braves | 5 | Aug 2 | Aug 6 | 6.2 runs | |
| Washington Senators | 5 | Sep 10 | Sep 14 | 6.2 runs | |
| New York Giants | 5 | Aug 17 | Aug 21 | 5.8 runs | |
| Washington Senators | 5 | Sep 5 | Sep 9 | 5.6 runs | |
| Chicago Cubs | 5 | May 17 | May 23 | 5.6 runs | |
| Cincinnati Reds | 5 | May 29 | Jun 2 | 5.4 runs | |
| Philadelphia Phillies | 5 | Jul 24 | Jul 28 | 5.2 runs | |
| Cincinnati Reds | 5 | Jul 19 | Jul 23 | 5.0 runs | |
| Chicago Cubs | 5 | Jul 5 | Jul 9 | 4.6 runs | |
| Philadelphia Phillies | 5 | Aug 2 | Aug 5 | 4.4 runs | |
| St. Louis Browns | 5 | Jul 7 | Jul 15 | 4.4 runs | |
| Washington Senators | 5 | Jul 4 | Jul 8 | 4.0 runs | |
| Cleveland Indians | 5 | May 13 | May 18 | 4.0 runs | |
| Pittsburgh Pirates | 5 | Sep 6 | Sep 10 | 3.8 runs | |
| Chicago Cubs | 5 | Jul 15 | Jul 19 | 3.6 runs | |
| Detroit Tigers | 5 | Jul 3 | Jul 6 | 3.4 runs | |
| Philadelphia Athletics | 5 | Aug 26 | Aug 31 | 3.2 runs | |
| Chicago White Sox | 5 | Sep 2 | Sep 5 | 3.0 runs | |
| Chicago White Sox | 5 | Sep 25 | Oct 1 | 2.8 runs | |
| New York Giants | 5 | Jun 6 | Jun 10 | 2.8 runs | |
| Pittsburgh Pirates | 5 | May 1 | May 6 | 2.8 runs | |
| Chicago White Sox | 5 | Jun 16 | Jun 19 | 2.6 runs | |
| Philadelphia Athletics | 5 | May 30 | Jun 3 | 2.4 runs | |
| Cincinnati Reds | 5 | Sep 10 | Sep 14 | 2.2 runs |
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