The Cincinnati Reds had the longest losing streak within the 2015 regular season at 13 straight games. During this streak they lost to their opponents by an average of 4.4 runs. The streak started on Sep 20, 2015 and ended on Oct 2, 2015.
| Team | Losing Streak | Start | End | Avg Margin of Defeat | |
|---|---|---|---|---|---|
| 1 | Cincinnati Reds | 13 | Sep 20 | Oct 2 | 4.4 runs |
| 2 | Atlanta Braves | 12 | Aug 25 | Sep 6 | 6.2 runs |
| 3 | Colorado Rockies | 11 | Apr 28 | May 13 | 4.5 runs |
| 4 | Cincinnati Reds | 9 | May 15 | May 25 | 4.0 runs |
| Cincinnati Reds | 9 | Aug 14 | Aug 23 | 2.6 runs | |
| Philadelphia Phillies | 9 | Jun 8 | Jun 17 | 4.3 runs | |
| 7 | Boston Red Sox | 8 | Jul 12 | Jul 23 | 3.5 runs |
| Chicago White Sox | 8 | Jun 12 | Jun 19 | 2.6 runs | |
| Detroit Tigers | 8 | May 28 | Jun 5 | 3.2 runs | |
| Miami Marlins | 8 | May 15 | May 22 | 2.8 runs | |
| Milwaukee Brewers | 8 | Apr 15 | Apr 22 | 3.5 runs | |
| Milwaukee Brewers | 8 | Sep 11 | Sep 19 | 2.8 runs | |
| San Francisco Giants | 8 | Apr 10 | Apr 17 | 3.5 runs | |
| 14 | Atlanta Braves | 7 | Aug 17 | Aug 23 | 4.0 runs |
| Boston Red Sox | 7 | Jun 9 | Jun 15 | 2.7 runs | |
| Houston Astros | 7 | Jun 4 | Jun 10 | 2.6 runs | |
| Milwaukee Brewers | 7 | May 23 | May 30 | 2.4 runs | |
| New York Mets | 7 | Jun 17 | Jun 24 | 3.1 runs | |
| Oakland Athletics | 7 | Aug 11 | Aug 17 | 4.6 runs | |
| Philadelphia Phillies | 7 | May 24 | May 31 | 3.3 runs | |
| San Francisco Giants | 7 | Aug 29 | Sep 4 | 2.9 runs | |
| San Francisco Giants | 7 | Jun 30 | Jul 6 | 2.3 runs | |
| Seattle Mariners | 7 | May 30 | Jun 5 | 2.1 runs | |
| Tampa Bay Rays | 7 | Jun 28 | Jul 4 | 3.3 runs | |
| 25 | Arizona Diamondbacks | 6 | Jul 10 | Jul 19 | 2.0 runs |
| Atlanta Braves | 6 | Jul 27 | Aug 1 | 4.3 runs | |
| Baltimore Orioles | 6 | Aug 27 | Sep 1 | 4.0 runs | |
| Baltimore Orioles | 6 | Aug 20 | Aug 25 | 3.7 runs | |
| Cleveland Indians | 6 | Jul 23 | Jul 28 | 4.5 runs | |
| Colorado Rockies | 6 | Aug 10 | Aug 15 | 4.0 runs | |
| Houston Astros | 6 | Jul 7 | Jul 12 | 2.0 runs | |
| Los Angeles Angels of Anaheim | 6 | Jul 28 | Aug 2 | 2.8 runs | |
| Miami Marlins | 6 | Aug 3 | Aug 8 | 4.3 runs | |
| Milwaukee Brewers | 6 | Jun 13 | Jun 18 | 4.3 runs | |
| Milwaukee Brewers | 6 | Jul 29 | Aug 3 | 3.7 runs | |
| New York Yankees | 6 | May 17 | May 24 | 4.0 runs | |
| Oakland Athletics | 6 | May 6 | May 11 | 3.7 runs | |
| Philadelphia Phillies | 6 | Sep 14 | Sep 20 | 3.0 runs | |
| Philadelphia Phillies | 6 | Apr 12 | Apr 17 | 2.8 runs | |
| Philadelphia Phillies | 6 | Jun 29 | Jul 4 | 2.3 runs | |
| San Diego Padres | 6 | Aug 4 | Aug 9 | 3.3 runs | |
| San Diego Padres | 6 | Jul 4 | Jul 10 | 1.5 runs | |
| Seattle Mariners | 6 | Sep 23 | Sep 28 | 2.3 runs | |
| Tampa Bay Rays | 6 | May 23 | May 29 | 3.0 runs | |
| Texas Rangers | 6 | Jun 20 | Jun 26 | 3.8 runs | |
| Washington Nationals | 6 | Aug 11 | Aug 16 | 4.0 runs | |
| Washington Nationals | 6 | Apr 22 | Apr 27 | 3.7 runs | |
| 48 | Atlanta Braves | 5 | Jun 23 | Jun 27 | 3.0 runs |
| Atlanta Braves | 5 | Jul 8 | Jul 12 | 2.8 runs | |
| Baltimore Orioles | 5 | Sep 25 | Sep 30 | 6.2 runs | |
| Baltimore Orioles | 5 | Apr 20 | Apr 24 | 3.6 runs | |
| Baltimore Orioles | 5 | May 30 | Jun 3 | 2.8 runs | |
| Chicago Cubs | 5 | Jun 24 | Jun 28 | 3.6 runs | |
| Chicago White Sox | 5 | Apr 29 | May 3 | 5.8 runs | |
| Colorado Rockies | 5 | Apr 17 | Apr 21 | 5.2 runs | |
| Colorado Rockies | 5 | Sep 20 | Sep 24 | 4.4 runs | |
| Colorado Rockies | 5 | Jun 15 | Jun 19 | 3.6 runs | |
| Detroit Tigers | 5 | Aug 21 | Aug 25 | 2.8 runs | |
| Houston Astros | 5 | Sep 14 | Sep 18 | 4.2 runs | |
| Los Angeles Angels of Anaheim | 5 | Jun 2 | Jun 7 | 3.4 runs | |
| Los Angeles Dodgers | 5 | Aug 18 | Aug 23 | 2.0 runs | |
| Miami Marlins | 5 | Jun 21 | Jun 26 | 3.8 runs | |
| Miami Marlins | 5 | Apr 16 | Apr 21 | 2.2 runs | |
| Minnesota Twins | 5 | Aug 2 | Aug 6 | 3.4 runs | |
| Minnesota Twins | 5 | Jun 8 | Jun 13 | 3.4 runs | |
| Minnesota Twins | 5 | Sep 15 | Sep 19 | 2.2 runs | |
| New York Mets | 5 | May 11 | May 15 | 3.0 runs | |
| New York Mets | 5 | Sep 29 | Oct 3 | 2.0 runs | |
| New York Yankees | 5 | Sep 8 | Sep 12 | 3.2 runs | |
| New York Yankees | 5 | Aug 7 | Aug 12 | 2.2 runs | |
| Oakland Athletics | 5 | Sep 19 | Sep 24 | 4.8 runs | |
| Oakland Athletics | 5 | Sep 1 | Sep 6 | 3.6 runs | |
| Philadelphia Phillies | 5 | Jul 8 | Jul 12 | 5.8 runs | |
| Philadelphia Phillies | 5 | Sep 2 | Sep 7 | 4.6 runs | |
| Philadelphia Phillies | 5 | Apr 28 | May 2 | 4.6 runs | |
| Pittsburgh Pirates | 5 | May 1 | May 6 | 2.4 runs | |
| San Francisco Giants | 5 | May 30 | Jun 3 | 3.4 runs | |
| San Francisco Giants | 5 | Jun 11 | Jun 15 | 2.4 runs | |
| Texas Rangers | 5 | Jul 3 | Jul 8 | 6.0 runs | |
| Toronto Blue Jays | 5 | May 13 | May 17 | 2.8 runs | |
| Washington Nationals | 5 | Sep 7 | Sep 12 | 1.8 runs |
In the 2015 MLB season, there were no losing streaks that were in the all time top 50 losing streaks in the same season.
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