Major League Baseball » Houston Astros » Biggest Losses
Based on run differential, the largest loss in Houston Astros history is by 16 runs, which has happened 7 times in Astros history.
The biggest postseason loss in Houston Astros history, by run differential, is by 10 runs which occured in a 3-13 loss to the Atlanta Braves during the NL Divisional Series on Oct 1, 1997.
The biggest home loss in Houston Astros history, by run differential, is by 16 runs, which has happened 3 times.
The biggest road loss in Houston Astros history, by run differential, is by 16 runs, which has happened 4 times.
The most runs the Houston Astros have ever allowed in a single game is 22 runs, which they gave up in a 7-22 loss to the Chicago Cubs on Jun 3, 1987.
| Opponent | Run Margin | Date | Score |
|---|---|---|---|
| Arizona Diamondbacks | 10 (2x) (2 times) |
Aug 15, 2008
May 25, 2007 |
2-12
3-13 |
| Atlanta Braves | 16 | May 8, 2005 | 0-16 |
| Baltimore Orioles | 10 | Jun 29, 2021 | 3-13 |
| Boston Red Sox | 16 | Aug 24, 2023 | 1-17 |
| Chicago Cubs | 15 | Jun 3, 1987 | 7-22 |
| Chicago White Sox | 9 (2x) (2 times) |
Jun 9, 2012
Jul 17, 2021 |
1-10
1-10 |
| Cincinnati Reds | 16 | Aug 3, 1989 | 2-18 |
| Cleveland Guardians | 13 | Apr 20, 2013 | 6-19 |
| Colorado Rockies | 16 | Sep 25, 2011 | 3-19 |
| Detroit Tigers | 15 | May 4, 2013 | 2-17 |
| Kansas City Royals | 10 (2x) (2 times) |
Apr 11, 2024
May 7, 2019 |
3-13
2-12 |
| Los Angeles Angels | 10 | Apr 4, 2014 | 1-11 |
| Los Angeles Dodgers | 12 (2x) (2 times) |
Sep 14, 1973
Sep 26, 1962 |
1-13
1-13 |
| Miami Marlins | 12 | Sep 17, 2008 | 2-14 |
| Milwaukee Brewers | 12 | Sep 5, 2007 | 2-14 |
| Minnesota Twins | 8 | Jun 7, 2014 | 0-8 |
| New York Mets | 16 | Aug 30, 1999 | 1-17 |
| New York Yankees | 13 | Jun 15, 2008 | 0-13 |
| Oakland Athletics | 14 | Sep 10, 2019 | 7-21 |
| Philadelphia Phillies | 16 | Sep 10, 1963 | 0-16 |
| Pittsburgh Pirates | 13 (2x) (2 times) |
Jul 23, 1967
Jul 22, 1967 |
2-15
2-15 |
| San Diego Padres | 15 | Apr 7, 1996 | 2-17 |
| San Francisco Giants | 14 | Apr 13, 1991 | 2-16 |
| Seattle Mariners | 13 | Jun 5, 2019 | 1-14 |
| St. Louis Cardinals | 15 | Apr 23, 1963 | 0-15 |
| Tampa Bay Rays | 12 | Jul 1, 2013 | 0-12 |
| Texas Rangers | 15 (2x) (2 times) |
May 21, 2005
Jul 4, 2004 |
3-18
3-18 |
| Toronto Blue Jays | 12 | Jun 16, 2019 | 0-12 |
| Washington Nationals | 16 | Jun 17, 1979 | 3-19 |
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