The 2008 Washington Nationals, the 2008 Kansas City Royals and the 2008 Seattle Mariners share the MLB record for the longest losing streak within the same season at 12 straight games.
In the 2008 MLB season, there were no losing streaks that were in the all time top 50 losing streaks in the same season.
| Team | Losing Streak | Start | End | Avg Margin of Defeat | |
|---|---|---|---|---|---|
| 1 | Washington Nationals | 12 | Aug 8 | Aug 20 | 4.6 runs |
| Kansas City Royals | 12 | May 19 | May 30 | 3.3 runs | |
| Seattle Mariners | 12 | Sep 11 | Sep 22 | 3.0 runs | |
| 4 | Pittsburgh Pirates | 10 | Aug 20 | Aug 31 | 5.2 runs |
| Cleveland Indians | 10 | Jun 28 | Jul 9 | 3.5 runs | |
| Oakland Athletics | 10 | Jul 28 | Aug 7 | 3.2 runs | |
| Baltimore Orioles | 10 | Sep 17 | Sep 26 | 2.3 runs | |
| 8 | Washington Nationals | 9 | Apr 3 | Apr 12 | 3.0 runs |
| Washington Nationals | 9 | Jul 22 | Jul 31 | 2.6 runs | |
| 10 | Baltimore Orioles | 8 | Aug 29 | Sep 6 | 5.9 runs |
| Los Angeles Dodgers | 8 | Aug 22 | Aug 29 | 4.9 runs | |
| Colorado Rockies | 8 | May 26 | Jun 2 | 4.6 runs | |
| Houston Astros | 8 | Jun 11 | Jun 19 | 3.6 runs | |
| Colorado Rockies | 8 | Jun 22 | Jun 30 | 3.4 runs | |
| San Diego Padres | 8 | Jun 21 | Jun 29 | 3.1 runs | |
| 16 | Texas Rangers | 7 | Apr 18 | Apr 24 | 6.1 runs |
| Kansas City Royals | 7 | Apr 17 | Apr 24 | 5.6 runs | |
| Seattle Mariners | 7 | Aug 15 | Aug 21 | 5.3 runs | |
| Seattle Mariners | 7 | May 20 | May 26 | 5.1 runs | |
| Tampa Bay Rays | 7 | Jul 7 | Jul 13 | 4.6 runs | |
| Kansas City Royals | 7 | Aug 16 | Aug 23 | 4.3 runs | |
| Detroit Tigers | 7 | Mar 31 | Apr 8 | 4.1 runs | |
| St. Louis Cardinals | 7 | Sep 10 | Sep 17 | 3.4 runs | |
| Seattle Mariners | 7 | Jul 19 | Jul 26 | 3.1 runs | |
| Colorado Rockies | 7 | Sep 6 | Sep 13 | 3.1 runs | |
| Toronto Blue Jays | 7 | Jun 14 | Jun 21 | 2.9 runs | |
| Cleveland Indians | 7 | May 16 | May 23 | 2.7 runs | |
| San Diego Padres | 7 | Aug 17 | Aug 24 | 2.3 runs | |
| Chicago White Sox | 7 | Apr 28 | May 5 | 1.6 runs | |
| 30 | Pittsburgh Pirates | 6 | Apr 15 | Apr 21 | 7.0 runs |
| Atlanta Braves | 6 | Aug 17 | Aug 22 | 5.0 runs | |
| Cincinnati Reds | 6 | Aug 5 | Aug 10 | 4.7 runs | |
| Minnesota Twins | 6 | Jun 5 | Jun 10 | 4.5 runs | |
| Detroit Tigers | 6 | Sep 19 | Sep 24 | 4.0 runs | |
| San Diego Padres | 6 | Jul 12 | Jul 20 | 3.7 runs | |
| Pittsburgh Pirates | 6 | Sep 6 | Sep 11 | 3.7 runs | |
| Chicago Cubs | 6 | Aug 30 | Sep 5 | 3.7 runs | |
| San Francisco Giants | 6 | Jul 6 | Jul 12 | 3.5 runs | |
| Milwaukee Brewers | 6 | May 2 | May 8 | 3.5 runs | |
| Detroit Tigers | 6 | Jul 31 | Aug 6 | 3.5 runs | |
| Arizona Diamondbacks | 6 | Sep 5 | Sep 10 | 3.3 runs | |
| Philadelphia Phillies | 6 | Jun 17 | Jun 24 | 3.3 runs | |
| Atlanta Braves | 6 | Jun 6 | Jun 12 | 3.2 runs | |
| Oakland Athletics | 6 | Jul 12 | Jul 21 | 2.7 runs | |
| Colorado Rockies | 6 | May 10 | May 16 | 2.7 runs | |
| Toronto Blue Jays | 6 | Apr 21 | Apr 26 | 2.5 runs | |
| San Francisco Giants | 6 | May 14 | May 19 | 2.3 runs | |
| Detroit Tigers | 6 | Sep 9 | Sep 16 | 2.3 runs | |
| Washington Nationals | 6 | Jul 2 | Jul 8 | 1.8 runs | |
| 50 | Houston Astros | 5 | Sep 14 | Sep 18 | 6.6 runs |
| Atlanta Braves | 5 | Aug 10 | Aug 15 | 5.8 runs | |
| Los Angeles Dodgers | 5 | May 7 | May 13 | 5.4 runs | |
| Milwaukee Brewers | 5 | Jul 27 | Jul 31 | 5.0 runs | |
| Cincinnati Reds | 5 | Jul 25 | Jul 29 | 5.0 runs | |
| Cincinnati Reds | 5 | Apr 29 | May 4 | 5.0 runs | |
| Texas Rangers | 5 | Sep 17 | Sep 22 | 4.8 runs | |
| Pittsburgh Pirates | 5 | Jul 13 | Jul 20 | 4.8 runs | |
| Los Angeles Dodgers | 5 | Jun 11 | Jun 15 | 4.6 runs | |
| Colorado Rockies | 5 | Apr 2 | Apr 6 | 4.6 runs | |
| Cincinnati Reds | 5 | Apr 11 | Apr 16 | 4.6 runs | |
| Seattle Mariners | 5 | May 6 | May 10 | 4.4 runs | |
| Houston Astros | 5 | May 28 | Jun 1 | 4.4 runs | |
| Detroit Tigers | 5 | May 2 | May 6 | 4.4 runs | |
| Atlanta Braves | 5 | Jul 26 | Jul 30 | 4.4 runs | |
| Washington Nationals | 5 | Sep 17 | Sep 21 | 4.2 runs | |
| Seattle Mariners | 5 | Apr 30 | May 4 | 4.2 runs | |
| Cincinnati Reds | 5 | Jun 14 | Jun 19 | 4.2 runs | |
| Minnesota Twins | 5 | Jul 20 | Jul 25 | 4.0 runs | |
| Oakland Athletics | 5 | Sep 23 | Sep 28 | 3.8 runs | |
| New York Mets | 5 | May 20 | May 23 | 3.8 runs | |
| Baltimore Orioles | 5 | May 21 | May 25 | 3.8 runs | |
| Arizona Diamondbacks | 5 | May 26 | May 30 | 3.8 runs | |
| Cincinnati Reds | 5 | Sep 24 | Sep 28 | 3.6 runs | |
| Baltimore Orioles | 5 | Jul 22 | Jul 26 | 3.6 runs | |
| San Diego Padres | 5 | Apr 21 | Apr 25 | 3.4 runs | |
| Milwaukee Brewers | 5 | Sep 11 | Sep 16 | 3.4 runs | |
| Chicago White Sox | 5 | Sep 23 | Sep 27 | 3.4 runs | |
| Atlanta Braves | 5 | Jun 28 | Jul 3 | 3.4 runs | |
| San Francisco Giants | 5 | Aug 29 | Sep 2 | 3.2 runs | |
| San Diego Padres | 5 | May 4 | May 9 | 3.0 runs | |
| Milwaukee Brewers | 5 | May 14 | May 18 | 2.8 runs | |
| Baltimore Orioles | 5 | Aug 22 | Aug 26 | 2.8 runs | |
| Texas Rangers | 5 | Apr 11 | Apr 15 | 2.6 runs | |
| St. Louis Cardinals | 5 | Jul 21 | Jul 25 | 2.6 runs | |
| San Francisco Giants | 5 | May 4 | May 9 | 2.6 runs | |
| Detroit Tigers | 5 | May 10 | May 16 | 2.2 runs | |
| Washington Nationals | 5 | Sep 9 | Sep 14 | 1.8 runs | |
| New York Mets | 5 | Jun 5 | Jun 10 | 1.8 runs | |
| Boston Red Sox | 5 | Apr 23 | Apr 27 | 1.8 runs | |
| Baltimore Orioles | 5 | May 3 | May 7 | 1.4 runs | |
| Boston Red Sox | 5 | Jun 28 | Jul 2 | 1.2 runs | |
| Baltimore Orioles | 5 | Jul 5 | Jul 10 | 1.2 runs |
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