| 10 | Atlanta Braves |
| Postseason Teams | World Series Winner |
The 2021 World Series winner was the Atlanta Braves, who defeated the Houston Astros in 6 games. The final game was on on Nov 2, 2021, in which the Braves won 7-0 on the road.
The 2021 World Series started on Oct 26, 2021 and ended on Nov 2, 2021, lasting 6 games.
The San Francisco Giants had the best regular season record in the 2021 MLB season at 107-55.
The Los Angeles Dodgers had the best run differential in the 2021 regular season at +269 runs.
The Baltimore Orioles had the worst run differential in the 2021 regular season at -297 runs.
The Houston Astros had the most runs per game in the 2021 regular season at 5.33 RPG.
The Los Angeles Dodgers allowed the fewest runs per game in the 2021 regular season at 3.46 runs allowed per game.
| Team | Record | Streak | RPG | RPG Allowed | Run Differential | Playoff Result |
|---|---|---|---|---|---|---|
| San Francisco Giants | 107-55 | W1 | 4.96 | 3.67 | +210 | Lost NLDS |
| Los Angeles Dodgers | 106-56 | W7 | 5.12 | 3.46 | +269 | Lost NLCS |
| Tampa Bay Rays | 100-62 | L1 | 5.29 | 4.02 | +206 | Lost ALDS |
| Houston Astros | 95-67 | W2 | 5.33 | 4.06 | +205 | Lost WS |
| Milwaukee Brewers | 95-67 | L4 | 4.56 | 3.85 | +115 | Lost NLDS |
| Chicago White Sox | 93-69 | L1 | 4.91 | 3.93 | +160 | Lost ALDS |
| Boston Red Sox | 92-70 | W3 | 5.12 | 4.62 | +80 | Lost ALCS |
| New York Yankees | 92-70 | W1 | 4.39 | 4.13 | +42 | Lost ALWC |
| Toronto Blue Jays | 91-71 | W3 | 5.22 | 4.09 | +183 | |
| St. Louis Cardinals | 90-72 | L2 | 4.36 | 4.15 | +34 | Lost NLWC |
| Seattle Mariners | 90-72 | L1 | 4.30 | 4.62 | -51 | |
| Atlanta Braves | 88-73 | W2 | 4.91 | 4.07 | +134 | Won WS |
| Oakland Athletics | 86-76 | L2 | 4.59 | 4.24 | +56 | |
| Cincinnati Reds | 83-79 | W1 | 4.85 | 4.69 | +26 | |
| Philadelphia Phillies | 82-80 | L2 | 4.53 | 4.60 | -11 | |
| Cleveland Indians | 80-82 | W1 | 4.43 | 4.49 | -10 | |
| San Diego Padres | 79-83 | L1 | 4.50 | 4.37 | +21 | |
| New York Mets | 77-85 | L2 | 3.93 | 4.12 | -32 | |
| Detroit Tigers | 77-85 | W1 | 4.30 | 4.67 | -59 | |
| Los Angeles Angels | 77-85 | W1 | 4.46 | 4.96 | -81 | |
| Colorado Rockies | 74-87 | L2 | 4.59 | 4.94 | -57 | |
| Kansas City Royals | 74-88 | L2 | 4.23 | 4.86 | -102 | |
| Minnesota Twins | 73-89 | W2 | 4.50 | 5.15 | -105 | |
| Chicago Cubs | 71-91 | W2 | 4.35 | 5.18 | -134 | |
| Miami Marlins | 67-95 | W2 | 3.85 | 4.33 | -78 | |
| Washington Nationals | 65-97 | L5 | 4.47 | 5.06 | -96 | |
| Pittsburgh Pirates | 61-101 | L1 | 3.76 | 5.14 | -224 | |
| Texas Rangers | 60-102 | L1 | 3.86 | 5.03 | -190 | |
| Arizona Diamondbacks | 52-110 | W2 | 4.19 | 5.51 | -214 | |
| Baltimore Orioles | 52-110 | L3 | 4.07 | 5.90 | -297 |
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