| 32-39-11 | Missed Playoffs |
| Record | Outcome |
The Buffalo Sabres finished the regular season with a 32-39-11 record. They went 17-18-6 at home and 15-21-5 on the road.
The 2021-22 Buffalo Sabres played in the Atlantic Division of the Eastern Conference.
No, the Sabres didn't make the Playoffs in 2022.
During the regular season, the 2021-22 Buffalo Sabres went 7-11 in overtime games.
In regular season games that ended in shootouts, the 2021-22 Buffalo Sabres went 3-3.
The longest win streak during the regular season for the 2021-22 Buffalo Sabres was a 4 game winning streak.
The longest losing streak that the Buffalo Sabres had during the 2021-22 regular season was 7 games, which happened once during the season.
= Playoff Team
| Date | Opponent | Score | |
|---|---|---|---|
| Regular Season | |||
| Thu, Oct 14, 2021 Thu, Oct 14, 2021 | vs Montreal Canadiens | Win 5 - 1 | |
| Sat, Oct 16, 2021 Sat, Oct 16, 2021 | vs Arizona Coyotes | Win 2 - 1 | OT/SO |
| Tue, Oct 19, 2021 Tue, Oct 19, 2021 | vs Vancouver Canucks | Win 5 - 2 | |
| Fri, Oct 22, 2021 Fri, Oct 22, 2021 | vs Boston Bruins | Loss 1 - 4 | |
| Sat, Oct 23, 2021 Sat, Oct 23, 2021 | @ New Jersey Devils | Loss 1 - 2 | OT |
| Mon, Oct 25, 2021 Mon, Oct 25, 2021 | vs Tampa Bay Lightning | Win 5 - 1 | |
| Thu, Oct 28, 2021 Thu, Oct 28, 2021 | @ Anaheim Ducks | Win 4 - 3 | OT |
| Sun, Oct 31, 2021 Sun, Oct 31, 2021 | @ Los Angeles Kings | Loss 2 - 3 | |
| Tue, Nov 2, 2021 Tue, Nov 2, 2021 | @ San Jose Sharks | Loss 3 - 5 | |
| Thu, Nov 4, 2021 Thu, Nov 4, 2021 | @ Seattle Kraken | Loss 2 - 5 | |
| Sat, Nov 6, 2021 Sat, Nov 6, 2021 | vs Detroit Red Wings | Loss 3 - 4 | OT |
| Mon, Nov 8, 2021 Mon, Nov 8, 2021 | @ Washington Capitals | Loss 3 - 5 | |
| Fri, Nov 12, 2021 Fri, Nov 12, 2021 | vs Edmonton Oilers | Win 3 - 2 | |
| Sat, Nov 13, 2021 Sat, Nov 13, 2021 | vs Toronto Maple Leafs | Loss 4 - 5 | |
| Tue, Nov 16, 2021 Tue, Nov 16, 2021 | @ Pittsburgh Penguins | Win 2 - 1 | |
| Thu, Nov 18, 2021 Thu, Nov 18, 2021 | vs Calgary Flames | Loss 0 - 5 | |
| Sun, Nov 21, 2021 Sun, Nov 21, 2021 | @ New York Rangers | Loss 4 - 5 | |
| Mon, Nov 22, 2021 Mon, Nov 22, 2021 | vs Columbus Blue Jackets | Loss 4 - 7 | |
| Wed, Nov 24, 2021 Wed, Nov 24, 2021 | vs Boston Bruins | Loss 1 - 5 | |
| Fri, Nov 26, 2021 Fri, Nov 26, 2021 | vs Montreal Canadiens | Win 4 - 1 | |
| Sat, Nov 27, 2021 Sat, Nov 27, 2021 | @ Detroit Red Wings | Loss 2 - 3 | OT |
| Mon, Nov 29, 2021 Mon, Nov 29, 2021 | vs Seattle Kraken | Loss 4 - 7 | |
| Thu, Dec 2, 2021 Thu, Dec 2, 2021 | @ Florida Panthers | Loss 4 - 7 | |
| Sat, Dec 4, 2021 Sat, Dec 4, 2021 | @ Carolina Hurricanes | Loss 2 - 6 | |
| Tue, Dec 7, 2021 Tue, Dec 7, 2021 | vs Anaheim Ducks | Loss 0 - 2 | |
| Fri, Dec 10, 2021 Fri, Dec 10, 2021 | vs New York Rangers | Loss 1 - 2 | |
| Sat, Dec 11, 2021 Sat, Dec 11, 2021 | vs Washington Capitals | Loss 2 - 3 | OT/SO |
| Tue, Dec 14, 2021 Tue, Dec 14, 2021 | @ Winnipeg Jets | Win 4 - 2 | |
| Thu, Dec 16, 2021 Thu, Dec 16, 2021 | @ Minnesota Wild | Win 3 - 2 | OT/SO |
| Fri, Dec 17, 2021 Fri, Dec 17, 2021 | @ Pittsburgh Penguins | Loss 2 - 3 | OT |
| Wed, Dec 29, 2021 Wed, Dec 29, 2021 | vs New Jersey Devils | Loss 3 - 4 | |
| Thu, Dec 30, 2021 Thu, Dec 30, 2021 | @ New York Islanders | Loss 1 - 4 | |
| Sat, Jan 1, 2022 Sat, Jan 1 | @ Boston Bruins | Loss 3 - 4 | OT |
| Thu, Jan 6, 2022 Thu, Jan 6 | vs San Jose Sharks | Loss 2 - 3 | |
| Tue, Jan 11, 2022 Tue, Jan 11 | vs Tampa Bay Lightning | Loss 1 - 6 | |
| Thu, Jan 13, 2022 Thu, Jan 13 | @ Nashville Predators | Win 4 - 1 | |
| Sat, Jan 15, 2022 Sat, Jan 15 | @ Detroit Red Wings | Loss 0 - 4 | |
| Mon, Jan 17, 2022 Mon, Jan 17 | vs Detroit Red Wings | Loss 2 - 3 | OT |
| Tue, Jan 18, 2022 Tue, Jan 18 | @ Ottawa Senators | Win 3 - 1 | |
| Thu, Jan 20, 2022 Thu, Jan 20 | vs Dallas Stars | Loss 4 - 5 | |
| Sat, Jan 22, 2022 Sat, Jan 22 | vs Philadelphia Flyers | Win 6 - 3 | |
| Tue, Jan 25, 2022 Tue, Jan 25 | @ Ottawa Senators | Loss 0 - 5 | |
| Sat, Jan 29, 2022 Sat, Jan 29 | @ Arizona Coyotes | Win 3 - 1 | |
| Sun, Jan 30, 2022 Sun, Jan 30 | @ Colorado Avalanche | Loss 1 - 4 | |
| Tue, Feb 1, 2022 Tue, Feb 1 | @ Vegas Golden Knights | Loss 2 - 5 | |
| Thu, Feb 10, 2022 Thu, Feb 10 | vs Columbus Blue Jackets | Loss 3 - 4 | OT |
| Sun, Feb 13, 2022 Sun, Feb 13 | @ Montreal Canadiens | Win 5 - 3 | |
| Tue, Feb 15, 2022 Tue, Feb 15 | vs New York Islanders | Win 6 - 3 | |
| Thu, Feb 17, 2022 Thu, Feb 17 | vs Ottawa Senators | Loss 1 - 3 | |
| Sat, Feb 19, 2022 Sat, Feb 19 | vs Colorado Avalanche | Loss 3 - 5 | |
| Sun, Feb 20, 2022 Sun, Feb 20 | @ Columbus Blue Jackets | Loss 3 - 7 | |
| Wed, Feb 23, 2022 Wed, Feb 23 | @ Montreal Canadiens | Loss 0 - 4 | |
| Fri, Feb 25, 2022 Fri, Feb 25 | @ St. Louis Blues | Loss 3 - 5 | |
| Sun, Feb 27, 2022 Sun, Feb 27 | @ Dallas Stars | Loss 2 - 4 | |
| Wed, Mar 2, 2022 Wed, Mar 2 | @ Toronto Maple Leafs | Win 5 - 1 | |
| Fri, Mar 4, 2022 Fri, Mar 4 | vs Minnesota Wild | Win 5 - 4 | |
| Sun, Mar 6, 2022 Sun, Mar 6 | vs Los Angeles Kings | Loss 0 - 3 | |
| Mon, Mar 7, 2022 Mon, Mar 7 | vs Florida Panthers | Loss 1 - 6 | |
| Thu, Mar 10, 2022 Thu, Mar 10 | vs Vegas Golden Knights | Win 3 - 1 | |
| Sun, Mar 13, 2022 Sun, Mar 13 | vs Toronto Maple Leafs | Win 5 - 2 | |
| Thu, Mar 17, 2022 Thu, Mar 17 | @ Edmonton Oilers | Loss 1 - 6 | |
| Fri, Mar 18, 2022 Fri, Mar 18 | @ Calgary Flames | Win 1 - 0 | OT |
| Sun, Mar 20, 2022 Sun, Mar 20 | @ Vancouver Canucks | Win 3 - 2 | OT |
| Wed, Mar 23, 2022 Wed, Mar 23 | vs Pittsburgh Penguins | Win 4 - 3 | OT/SO |
| Fri, Mar 25, 2022 Fri, Mar 25 | vs Washington Capitals | Loss 3 - 4 | OT/SO |
| Sun, Mar 27, 2022 Sun, Mar 27 | @ New York Rangers | Loss 4 - 5 | OT |
| Mon, Mar 28, 2022 Mon, Mar 28 | @ Chicago Blackhawks | Win 6 - 5 | |
| Wed, Mar 30, 2022 Wed, Mar 30 | vs Winnipeg Jets | Loss 2 - 3 | OT/SO |
| Fri, Apr 1, 2022 Fri, Apr 1 | vs Nashville Predators | Win 4 - 3 | |
| Sun, Apr 3, 2022 Sun, Apr 3 | vs Florida Panthers | Loss 3 - 5 | |
| Tue, Apr 5, 2022 Tue, Apr 5 | vs Carolina Hurricanes | Win 4 - 2 | |
| Thu, Apr 7, 2022 Thu, Apr 7 | @ Carolina Hurricanes | Loss 3 - 5 | |
| Fri, Apr 8, 2022 Fri, Apr 8 | @ Florida Panthers | Loss 3 - 4 | |
| Sun, Apr 10, 2022 Sun, Apr 10 | @ Tampa Bay Lightning | Loss 0 - 5 | |
| Tue, Apr 12, 2022 Tue, Apr 12 | @ Toronto Maple Leafs | Win 5 - 2 | |
| Thu, Apr 14, 2022 Thu, Apr 14 | vs St. Louis Blues | Loss 2 - 6 | |
| Sat, Apr 16, 2022 Sat, Apr 16 | vs Philadelphia Flyers | Win 4 - 3 | |
| Sun, Apr 17, 2022 Sun, Apr 17 | @ Philadelphia Flyers | Win 5 - 3 | |
| Thu, Apr 21, 2022 Thu, Apr 21 | @ New Jersey Devils | Win 5 - 2 | |
| Sat, Apr 23, 2022 Sat, Apr 23 | vs New York Islanders | Win 5 - 3 | |
| Thu, Apr 28, 2022 Thu, Apr 28 | @ Boston Bruins | Loss 0 - 5 | |
| Fri, Apr 29, 2022 Fri, Apr 29 | vs Chicago Blackhawks | Win 3 - 2 | OT |
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